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Chunk #30 — DISCUSSION

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Genome-wide association study identifies a novel locus for cannabis dependence.
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There was also nominal evidence that rs1409568 genotype was associated with changes in CpG methylation of TIAL1. C allele carriers, on average, had lower methylation scores than T homozygotes. There is no published evidence for a role of the RNA-binding protein encoded by this gene in addictive processes.