There other examples of mutations in sequences encoding 3′ UTRs that do not act via the UTR. A single nucleotide polymorphism that determines susceptibility to an autoimmune thyroid disease occurs both within the 3′ UTR of the ZFAT gene (zinc-finger gene in AITD susceptibility region) and also within the promoter of an antisense transcript (SAS-ZFAT), and increases the expression of ZFAT not through increasing mRNA stability, but by repressing the expression of the antisense transcript [172].
