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Chunk #46 — Materials and Methods — Identification of Genes That Contained Convergent Data from Two Samples: 2) “Cluster Than Converge”

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Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
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Monte Carlo I assessments [36] thus provided p values for the extent to which clustering of nominally positive SNPs (from each of 2 samples in “converge then cluster” approach and from each sample in “cluster then converge” approach) differed from chance. Monte Carlo II assessments [36] provided p values for the degree to which clusters identified in one of the samples from the “cluster then converge” approaches were found in the same genes as those identified by clusters from the other sample. Monte Carlo III assessments [36] provided p values for the likelihood of finding of sets of nominally-positive SNPs in segments of each of the genes identified here (Johnson et al, in preparation).