to 50%. The exact weighted median estimate in this case will be β^WM=β^3+(β^4−β^3)×50−27.7852.78−27.78.The weighted median can also be thought of as the simple median from a set of values (a pseudopopulation) in which the ratio estimate β^1 for variant 1 appears 100×w1 times, ratio estimate β^2 for variant 2 appears 100×w2 times, and so on. R code to calculate weighted median estimates, confidence intervals, standard errors and P‐values is provided in Supporting Information Appendix 2.
