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Chunk #35 — Results — RNA Expression Array Analysis Identifies Candidate Mediators of Zfhx1b Function

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Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.
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We were most interested in genes that were altered in both the Nkx2.1-Cre and DlxI12b-Cre Zfhx1b mutants, given that both mutants showed altered interneuron migration and specification. Six genes fell into this category: cMaf, MafB, CXCR7, Dlk1, Cited1 andGpc4 (Figures 7, S6). Dlk1, Cited1 and Gpc4 were up-regulated in the MGE both mutants (Figure S6). cMaf, MafB, and CXCR7 were down-regulated in the MGE and migrating interneurons; later in the paper we focused more on these genes (Figures 7, S6); below we discuss the other genes.