independent of ongoing dicer activity (Lugli et al., 2005). Recent studies in Drosophila and rodents have confirmed the importance of components of the RISC complex at the synapse, which was necessary for the establishment of certain forms of short and long-term memories in these models (Ashraf et al., 2006; Batassa et al., 2010). Remarkably, we found that dicer was downregulated in the PFC of human alcoholics and that, equal to CXCR4, it was the mRNA most significantly over-targeted by upregulated miRNAs (Lewohl et al., 2011), which suggest a relevant role for dicer-miRNA feedback loops in the mediation of and/or neuroadaptation to alcohol actions.
