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Chunk #13 — RESULTS — Enrichment analyses

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Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
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For TS, OCD, and the combined sample, we examined the subset of disease association p-values for SNPs meeting stringent criteria for eQTLs (peQTL<10−6) derived from cerebellum, parietal cortex and frontal cortex, as well as cerebellar mQTLs (pmQTL<10−6) (Figure 2). Using the field standard FDR threshold of <0.25, we identified 38 cerebellar eQTLs from five LD-independent loci for TS, 161 cerebellar mQTLs (19 LD-independent loci) for OCD, and 53 parietal cortex eQTLs (four LD-independent loci) for the combined GWAS (Table 2).