(Ficz et al., 2011; Guo, Su, Zhong, Ming, & Song, 2011; Mellen et al., 2012; Song et al., 2011; Yu et al., 2012). TET1 has also been implicated as a key molecule in synaptic plasticity and memory mechanisms through regulation of Arc thereby modulating extinction of fear memories (Kaas et al., 2013; Rudenko et al., 2013). Studies have also implicated the Growth arrest and DNA damage (Gadd45) family of proteins to be important for DNA demethylation and suggested a role for this pathway in hippocampal synaptic plasticity associated learning and memory (Barreto et al., 2007; Ma et al., 2009; Sultan, Wang, Tront, Liebermann, & Sweatt, 2012). These studies have brought DNA demethylation into the limelight and more importantly suggest that even a ‘stable’ mark such as cytosine methylation is subject to dynamic regulation. Let us now look at the effects of ethanol on DNA methylation and de-methylation networks and the phenotypic outcomes.
