Despite the fundamental link between cannabis and the eCB system, human genetics studies have not reliably linked eCB genetic polymorphisms to cannabis-related outcomes (Agrawal & Lynskey, 2009; Verweij et al., 2012). Here, we found evidence that rs604300 genotype in MGLL moderates the relationship between CSA and cannabis dependence symptoms. Those who carried two copies of the major G allele were at increased risk for cannabis dependence as a function of increasing exposure to CSA events. This finding was not surprising, as CSA has been widely documented as a potent contributor to the etiology of a host of addictive behaviors, including cannabis dependence (Duncan et al., 2008; Fergusson et al., 1996; Myers & Prescott, 2000; Nelson et al., 2006; Simpson & Miller, 2002). What was particularly intriguing was that rs604300 minor A allele carriers did not demonstrate increased vulnerability to cannabis dependence symptoms in the presence of CSA exposure. This alludes to the potential buffering effects of the A allele in rs604300 on the pathogenic effects of CSA. This is highly congruent not only with one prior study of eCB genotypes
