While the loss of neurons is a common feature of AD, it is not clear whether the mechanism holds true across different forms of AD or AD cases carrying different genetic risk variants. Therefore, we investigated whether AD with distinct etiologies showed different cellular compositions. We generated RNA-seq data from the parietal lobe of participants enrolled in Knight-ADRC (84 LOAD, 3 ADAD, and 16 neuropath-free controls) and DIAN (19 ADAD) studies (Table 1; Additional file 1: Table S1). We selected the LOAD and ADAD participants to match for CDR at death, brain weight, and sex distributions (see Additional file 1: Table S1).
