In fact, the largest allele frequency difference occurred at 1 life event (δ, 0.045; SE, 0.020), which was of nominal significance, but none of the differences in any of the strata was statistically significant after adjusting for multiple testing. Furthermore, the findings of an increase in the S frequency at 1 life event is clearly at odds with the original findings of Caspi et al10 (eTable 2), for which the allele frequency difference is in the opposite direction (δ, −0.091; SE, 0.069). Therefore, in this case, stratifying the allele frequency test based on the environmental exposure did not provide additional support for a genetic association.
