paperKB
coga / coga-kb
Help
Sign in

Chunk #45 — Discussion — mPFC-BLA interactions during fear and safety

Source
Fear and safety engage competing patterns of theta-gamma coupling in the basolateral amygdala.
Embedded
yes

Text

engaged during relative safety, suppressing fear. The finding that extinction induces remodeling of perisomatic inhibitory synapses from parvalbumin positive (PV+) interneurons onto pyramidal cells in the amygdala (Trouche et al., 2013) raises the intriguing possibility that this interneuron subtype may participate in the putative gamma-generating microcircuit; PV+ interneurons are implicated in gamma generation in the hippocampus and neocortex (Lasztóczi and Klausberger, 2014; Sohal et al., 2009).