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Chunk #60 — ONLINE METHODS — Biological annotation.

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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
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We also used stratified LD Score regression21 to partition the heritability of the trait between SNPs of different types. In addition to the baseline SNP-level annotations (Supplementary Table 31), we tested a number of novel annotation types, described more fully in the Supplementary Note. We tested the heritability enrichment of neural cell types (Supplementary Table 9), various SNP-level annotations assembled by Pickrell46 (Supplementary Figure 23, Supplementary Table 32), developmental stages (Supplementary Table 33), and genes that are broadly expressed or specifically expressed in a particular tissue (Supplementary Figure 24, Supplementary Table 34). We also applied LD Score regression to DEPICT-reconstituted gene sets (Supplementary Table 35) and binary gene sets (Supplementary Table 36 and Supplementary Figure 25).