COPDGene will apply three general analytical strategies for the genome-wide SNP data to both maximize statistical power in identifying disease susceptibility loci (DSL) and minimize false positive results. 1. Immediate identification of DSL achieving genome-wide significance (using methods for screening and testing in the same dataset 16), 2. Ranking SNPs based on estimated effect size for 2-Stage design, and 3. Combining results across racial groups through either meta-analytic techniques or by incorporating covariates that summarize genetic background.
