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Chunk #36 — BACKGROUND — New perspectives with clinical relevance

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An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.
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importance of establishing longitudinal studies to examine the beneficial and potential harmful effects of medication on the developing brain and; second, the fact that disease chronicity is related to marked morphological alterations of the brain might provide additional incentive to invest in the implementation of state‐of‐the‐art interventions (e.g., exposure treatment requires significant scale up across the globe) and the development of innovative treatments for those who do not respond to first line interventions.