paperKB
coga / coga-kb
Help
Sign in

Chunk #11 — METHODS — Identity-by-descent analysis

Source
Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.
Embedded
yes

Text

Using genotyping data generated by the Illumina Omni Express chip and PLINK33, SNPs were pruned using pairwise genotypic correlation to identify informative markers and then IBD (Identity-by-Descent) proportions were calculated between all individuals. IBD estimates were compared with expected values to affirm relationships between the family members34.