We also regressed height at 17 years in ALSPAC and at 31 years in NFBC1966 on an allelic score constructed from the genome-wide significant SNPs for ‘Age at first tooth’ and ‘Number of teeth’ listed in Table 1. Allelic scores for ‘Age at first tooth’ (PMETA = 0.0012) and ‘Number of teeth’ (PMETA = 9.8 × 10−4) showed moderate evidence of association with height; however, the associations appeared to be driven largely by variants in HMGA2 and BMP4. After these SNPS were removed from the construction of the scores, the evidence for association attenuated markedly (‘Age at first tooth’ PMETA = 0.11; ‘Number of teeth’ PMETA = 0.04).
