Chunk #37 — 4. WIP1 SUPPRESSES THE STRESS RESPONSE: UPDATE — 4.3. Wip1 and the UV response — 4.3.1. UV-induced Wip1 expression — 4.3.1.3. Dose-dependence

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Regulation of the Wip1 phosphatase and its effects on the stress response.

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block of PPM1D transcription (59, 60). Additionally, the sustained phosphorylation of p53 on S15 and increased level of apoptosis that result from exposure to high doses of UVC radiation are consistent with the lack of Wip1 induction (61). The authors conclude that whereas Wip1 is induced in a p53-dependent manner in response to a low dose of UV radiation, high doses of UVC radiation suppress Wip1 induction in a p53-independent manner and disrupt the p53/Wip1 negative feedback loop (61).