The experimental subjects were sixty-five male mice, 37 of the DBA/2 strain and 28 of the C57BL/6 strain obtained from The Scripps Research Institute breeding facility, weighing between 19-30 grams. Mice were housed 3-4 per cage in controlled temperature and lighting conditions, with food and water ad libitum, for the duration of the study. The work described herein adheres to the guidelines stipulated in the NIH Guide for the Care and Use of Laboratory Animals (NIH publication No. 86-23, revised 1985) and was reviewed and approved by The Scripps Research Institute’s Institutional Animal Care and Use Committee.
