Chunk #91 — Methods — Differential methylation and contribution to ancestry differential expression — Differentially methylated region analysis

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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.

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For differentially methylated region analysis, we applied a linear model on VMRs (see ‘VMR analysis’) as a function of: (1) global genetic ancestry; (2) local genetic ancestry; (3) sex; (4) age; and (5) top five principal components of DNA methylation derived from the top one million variable CpGs. We corrected both statistical tests for multiple testing using the Benjamini–Hochberg method.