Chunk #22 — Epigenetics-Relevant Consequences of Oxidative Alcohol Metabolism — Increases in NADH/NAD+ Ratio and Their Consequences — Modulation of Gene Expression
The NADH/NAD+ ratio influences gene expression through several pathways. The following discussion focuses on three NAD+-dependent enzymes: carboxyl-terminal binding protein (CtBP); silent information regulator (Sir2); and the heterodimeric Clock/NPAS2 transcriptional regulator, whose activities may play a role in ethanol-induced injury.
