We used FINEMAP35 to fine-map regions defined by LD clumps (r2>0.1), excluding the MHC locus due to its complex LD structure. Clumps which overlapped (without adding the additional 50kb used to define physically distinct loci) were combined. As fine-mapping requires data from all markers in the region36 we only performed fine-mapping on regions that attained genome-wide significance (GWS) in the core PGC GWAS. In total, we attempted to fine-map 255 non-overlapping regions (Supplementary Table 11e). Further details about the fine-mapping process are given in the Supplementary Note.
