Many patients seeking treatment for addiction have multiple drug dependencies and psychiatric comorbidities (Volkow and Li 2005). Information from epidemiological surveys indicates that drug addiction is a common phenomenon and is associated with significant effects on both morbidity and mortality. Large individual and societal costs of drug abuse make research and treatment of drug addiction imperative (French et al. 2000; Mark et al. 2001). Recently through intensive clinical neurophysiological research and biological psychiatric studies many specific components of cognitive, emotional, and behavioral deficits typical for SUD have been identified and investigated. However, the practical values of these cognitive neuroscience and applied psychophysiology-based treatment (e.g., neurofeedback) findings depend on a further integration of these methodological approaches.