the basal levels of pAKT and pS6 are very low in both DCX+ immature neurons and DCX- mature neurons (Figure 1), indicating the existence of an active mechanism to keep AKT signaling in check. Our in vitro biochemical study and in vivo “single-cell genetic” analysis suggest that DISC1 serves as a key intrinsic modulator of AKT signaling in regulating the morphogenesis and tempo of dendritic development of new neurons in the adult brain.
