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Chunk #9 — Results

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Subspecialization within default mode nodes characterized in 10,000 UK Biobank participants.
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As a recurring theme across the 19 functional modes of population covariation, several coupling profiles showed one DMN subregion dominating intra-DMN connectivity in the context of broad network reconfiguration. The bilateral anterior TPJs (TPJ-1) were found to dominate in the DMN−networks correspondence (Fig. 4), as these two subregions showed prominent coupling increases in three modes. In the first mode of DMN−networks correspondence (r = 0.83), both anterior TPJs were increasingly coupled with most other DMN subregions, and the subregions of the left and right hippocampus increased their coupling among each other. Concurrently, at the global network level, the DMN was disengaged from the saliency network. Further, the somatomotor networks were more coupled among each other, increased in coupling with the medial temporal lobe and superior temporal gyrus, as well as decreased in coupling with the cerebellum and basal ganglia. In mode 5 (r = 0.72), the right anterior TPJ showed increased coupling with most DMN subregions, in particular with the posteromedial cortex (PMC-1/2/3/4), midline parts of the ventromedial prefrontal cortex (vmPFC-1/3) and dorsomedial prefrontal cortex (dmPFC-1/2/3/4). Concurrently, the overall DMN