In conclusion, in our large GWAS meta-analysis including up to 263,407 individuals, we identified four new loci influencing height detected at the tails, as well as seven new loci for clinical classes of obesity. Consistent with theoretical predictions and previous smaller studies, our results show that there is a large overlap in terms of genetic structure and distribution of variants between traits based on different distribution cutoffs with those from population-level studies, but additional insight may still be gained from evaluating the extremes. Our results are informative for designing future genetic studies of obesity as well as other complex traits.
