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Chunk #18 — MATERIALS AND METHODS — LASSO estimation

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Classification and selection of biomarkers in genomic data using LASSO.
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While Tibshirani [11] considered estimating coefficients in regression models using LASSO, our interest is in using gene expression data to classify tumors. In particular, we seek to extend the LDA approach advocated by Dudoit et al [7] to handle the case where p is larger than n. We outline the proposed method in the next section.