Grayson, & Morrow, 1995), specifically an increase in GABAA α4 (GABRA4) subunit and a decrease in expression of the α1 (GABRA1) subunit. Furthermore, studies performed using post-mortem human brain tissue found variations in γ2 (GABRG2) (Enoch et al., 2012) and δ (GABRD) (Bhandage et al., 2014) subunit expression. To properly determine the impact of alcohol on GABAA receptor function, Lieberman et al. generated iPS cell-derived neural cultures from both alcoholic and non-alcoholic donors and investigated the expression and function of GABAA receptor subunits in response to acute and chronic alcohol exposure.
