Of the 8 intronic SNPs analyzed during phase 1 (discovery) genotyping, all were found to be in HWE except rs4837479 (p = 0.002) and rs947513 which deviated in controls (p = 6.39E-12), in the AA population. Phase 1 genotyping included AA population (TRC) consisting of 796 cases and 416 controls. Single marker Chi-squared analysis for the SNP rs1342043 in AA (TRC population) showed a highly significant allelic (p = 0.005, OR = 0.78) as well as genotypic association (p = 0.0005) and both of these tests withstood correction for multiple testing (q-value < 0.05). The MAF of the C allele in controls for rs1342043 (40% controls vs 34% in cases) was found to be higher and therefore may act as a protective allele against CA (Table 2A). When comparing genotypic and allelic distributions between cocaine-addicted and control samples, none of the other SNPs remained statistically significant after correction for multiple testing (Table 2A). Furthermore, we carried out sex specific analyses on the phase 1 genotyping. rs1342043 showed significant genotypic association (p = 0.005) in males. The MAF of C allele
