Genetics research, in particular population genetics, is currently a contentious issue in AI/AN tribal communities.65 For example, thus far, no AI/AN sovereign nations have chosen to participate in the HapMap or 1000 Genomes Project. Consequently, this might lead to difficulties in SNP imputation for future AI/AN genetic studies. Nevertheless, there is now anonline guide to participation in genetic research to assist decision making by individual tribal governments that has been developed by the National Congress of American Indians Policy Research Center with support from the National Human Genome Research Institute, NIH.65