As defined and annotated by the UCSC genome browser (http://genome.ucsc.edu), 489 SNPs mapped to regions of regulatory potential, 177 to non-coding exons (including DISC2) and 36 to coding regions of exons. Of these 36 variants, 12 were synonymous changes, 23 were non-synonymous changes, with one producing a stop codon consistent with the DISC1 Es isoform (Figure 1; Supplementary Figure S3; Supplementary Tables S1 and S2). Supplementary Table S3 summarises the overlap between variants identified in this study and other DISC1 sequencing studies and relevant association studies.10, 11, 13, 14, 16, 17, 23, 46
