Previous GWA studies of BD have implicated several potential susceptibility genes, with ANK3 on chromosome 10q21.2 and CACNA1C on chromosome 12p13.3 featuring prominently in a large collaborative GWA meta-analysis study (54). In this study, p values of 1.3×10−8 and 7.0×10−8 were observed for rs1938526 in ANK3 and rs1006737 in CACNA1C, respectively, in a sample of 4,387 cases and 6,209 controls. A comparison of these results with the current sample fails to find support for association for these two SNPs with any of the five temperaments (p>0.05). Each temperament did produce associations elsewhere in these two genes with p values in the range of 0.05–0.0005 for many SNPs within ANK3 and CACNA1C. However, given the distance of these SNPs from those originally reported, these associations do not constitute a replication of association to these genes.
