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Chunk #58 — Discussion — Limitations and Future Directions

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Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features.
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We suggest that future studies overcome the limitations of the present study to further advance the field, by attempting: (i) to examine the brain circuitries underlying reward/outcome processing in high risk individuals by using coherence/synchrony measures of electrophysiology and by using functional connectivity measures of neuroimaging; (ii) to examine the trajectories of reward-related ERO activity in HR subjects and to delineate longitudinal changes associated with ERO measures in HR subjects using multiple assessments over a period of time; (iii) to extend the study to examine EROs in several externalizing disorders (considered as a spectrum) along with alcohol use disorders; (iv) to include multiple measures of impulsivity and externalizing features in AUD and HR subjects to understand the complex interactions among these factors; (v) to examine, in addition to the outcome processing analyzed in the current study, the decision making aspect, which might prove to be more sensitive in younger HR samples; (vi) to compare the absolute ERO power with the baseline normalized power and to utilize possible complementary merits in both approaches, (vii) to study the effects of genetic variants