Before the publication of recent genome-wide association (GWA) studies,1–3 the sequence variant having the strongest evidence for unconditional association with schizophrenia was rs1344706[T]. This variant was reported to be associated with schizophrenia with an odds ratio (OR) of 1.12 and a P-value of 1.6×10−7. Evidence for association was strengthened (OR = 1.12, P = 1.0×10−8) when a psychosis phenotype (schizophrenia plus bipolar disorder) was assessed.4 More recently, rs1344706 was shown to be associated with alterations in the functional connectivity of various regions of the brain.5 The single-nucleotide polymorphism (SNP) is located in an intron of ZNF804A, a gene encoding a protein predicted to be a transcription factor.
