We detected 1,858 different coding sequence variants, 1,769 from the X-specific and 89 from the pseudoautosomal X-chromosome regions (Table 2). We found that 1,814 were single-nucleotide changes: of these, 980 caused missense amino-acid substitutions, 22 caused nonsense (termination) codons, 13 were abnormalities at highly conserved bases at splice acceptor and donor sites and 799 were synonymous (silent) changes. Three variants were missense double-nucleotide substitutions, and 41 variants were small insertions and deletions, of which 26 were in-frame and 15 caused translational frameshifts.
