The most strongly-associated non-genic regions contain multiple peaks of high regulatory potential, but no known regulatory elements. Strong associations in non-genic regions should not be ignored; for example, several cancers are strongly associated with non-genic SNPs on chromosome 8q2461, whose functional relevance is now under intensive study. In secondary analyses, very low P-values were observed in non-genic regions (3q26.32 in females, Broad phenotype, P = 3.85 × 10−8; 3p14.1 in males, Narrow phenotype, P = 3.81 × 10−8. These values are not significant after accounting for multiple testing, and on 3q26.32 there is no support from other SNPs in the region (Figure S16).
