It is notable that two previously documented schizophrenia loci, at 15q11.2 and 15q13.3, were each found more than once as de novos (Table 1). Two other loci were represented by two de novo CNVs each: EHMT1 (encoding Eu-HMTase1), a histone H3 Lys 9 (H3-K9) methyltransferase, and DLG2 (encoding discs, large homologue 2). Moreover, one de novo spanned each of the related genes DLG1 (whose orthologue in Drosophila is also dlg1) and DLGAP1 (encoding discs large associated protein 1).
