hPSCs maintain the ability to self-renew indefinitely and can be differentiated into a wide range of cell types, making them an excellent source of differentiated cells for preclinical and clinical applications. However, several studies have reported genetic, epigenetic and transcriptional variation among hPSC cultures (Bock et al., 2011; Chin et al., 2009; Feng et al., 2010; Gore et al., 2011; Hough et al., 2009; Hussein et al., 2011; Kim et al., 2007; Laurent et al., 2011; Lister et al., 2011; Marchetto et al., 2009; Ohi et al., 2011), which may affect their differentiation propensities and utility for disease modeling, cell therapy, and drug development (Bock et al., 2011; Pomp et al., 2011; Tchieu et al., 2010; Urbach et al., 2010).
