Our analysis of the association between nicotine dependence and the SNP rs1451240was combined into a meta-analysis with an independent study of nicotine dependence(6). The previously published study had some subjects that overlapped with the current study. Using the published odds ratio from this study, and eliminating the overlapping subjects from our current study, we computed a meta-analysis p-value of 6.7×10−16 (n=4,200 subjects), further evidence that this association is, indeed, real.
