paperKB
coga / coga-kb
Help
Sign in

Chunk #18 — Online methods — Annotation of susceptibility loci

Source
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
Embedded
yes

Text

We combined multiple sources of in silico functional annotation from public databases to help identify potential functional SNPs and target genes, based on previous observations that cancer susceptibility alleles are enriched in cis-regulatory elements and alter transcriptional activity. The details are described in the Supplementary Note.