We observed selective localization within physiologically or pathogenically-relevant specific cell or tissue types, including affected tissues or known or posited effector cell types (Fig. 1C). For a given disorder, cell-selective localization within physiologically or pathogenically-relevant cell types was repeatedly observed for multiple independently-associated SNPs distributed widely around the genome (fig. S4). These results suggest a tissue-specific regulatory role for many common variants, as well as the potential for comprehensive regulatory DNA maps to illuminate associations within disease-relevant cell types.
