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Chunk #24 — Results — Immediate Recall, Delayed Recall, and Functional Connectivity in the DMN

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The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall.
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We further examined the relationship between the remote FC and the two memory variables. All nine brain regions whose ReHo values showed a significant correlation with AVLT-TR were defined as the ROIs. After calculating a 9x9 correlation matrix between the time course of ROIs and the time series of all other ROIs and extracting the mean FC value of each ROI, we conducted correlation analyses between FC values in the ROIs and memory performance. No significant correlations between FC and IR scores or between FC and DR scores in brain regions not belonging to the DMN (after Bonferroni correction) were found. However, when focusing on regions located in the DMN, i.e., the PHG, mPFC, PCC/PCu, and IPL, the results were interesting. Although there were no significant correlations between FC values and IR scores, significant correlations were found between FC within the DMN and DR scores (Figure 3). More specifically, DR scores were significantly associated with PHG-MFG connectivity (r = 0.405, p = 0.001), PHG-PCC connectivity (r = 0.409, p = 0.001), and PHG-IPL connectivity (r = 0.385, p = 0.001).