Current knowledge is mostly inferred from animal studies; it has been demonstrated that the main psychoactive component of cannabis (Δ9-Tetrahydrocannabinol, THC) induces dose-dependent toxicity and structural changes in brain regions rich in cannabinoid CB1 receptors. These are mainly located in the hippocampus, amygdala, cerebellum, prefrontal cortex, and striatum (Burns et al, 2007; Downer et al, 2001; Lawston et al, 2000).
