Three markers (rs2832407 in intron 9, rs2186305 in intron 17, and rs2832387 in the 3’UTR) showed nominally significant allelic association to AD in this sample (Table 2). Accounting for multiple comparisons, we compared the minimum p-value among the seven markers (0.009 for rs2832407) to the empirical distribution of the minimum p-value among the seven markers from the 10,000 permuted samples. A total of 425 permuted samples had the minimum p-value less than 0.009, suggesting that there is statistically significant evidence (an empirical p-value of 0.0425) when the minimum p-value is considered for multiple comparison adjustments.
