Prior meta-analyses in European ancestry populations have reported additional association signals distinct from bin A, and they cluster into three groups. Bin B, a group of 111 variants highly correlated in Europeans, includes the previously reported associated SNPs rs588765 and rs880395. The association with bin B previously reported in Europeans was seen only in association analyses conditioning on rs16969968 [2]. Bin B consists of 39 sub-bins in Asian subjects and 37 sub-bins in African American subjects. In conditional analyses, we found evidence of association between bin B and heavy smoking in the Asian data (OR=1.30, 95% C.I.= 1.07–1.58, p=9.7×10−3), as well as reproducing the European ancestry finding (OR=1.27, 95%C.I.=1.16–1.38, p=8.7×10−8). In the African American data, there was a trend toward association in the same direction (OR=1.16, 95%C.I.=0.99–1.36, p=0.064).
