The most significant SNP in the African-American sample, rs1881492 in CHRNG, is also modestly associated in European-Americans, but the odds ratios are in opposite directions (OR = 1.57 (1.17-2.11) in African-Americans; OR=0.77 (0.66-0.90) in European-Americans). For the other gene regions nominally associated in African-Americans – CHRNA7 and CHRNA10 – there is little evidence for association with nicotine dependence in European-Americans, even though the latter sample is larger. However, we note that in the CHRNA10 region, rs2231532 (OR = 1.35 (1.07-1.70), p=0.0108 in AAs versus OR = 1.07 (0.94-1.22), p=0.285 in EAs) is also associated with “dizziness in response to tobacco” in the original European-American subset of this sample (Ehringer et al., 2010).
