Our special issue in Psychophysiology was a step forward in the systematic evaluation of genetic associations for electrophysiological endophenotypes, but it is far from the last word. Electrophysiological endophenotypes are not dead, despite their apparent inability to dramatically increase power for genetic association studies. Endophenotypes, by their definition, are biological lab-based measures of genetically-influenced components of clinical disorders. As such, they provide insight into the nature of mental disorders and brain function. Of interest, then, is how to optimize their potential contribution.
