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Chunk #8 — Subjects and Methods — Replication sample

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Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.
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major Axis I psychiatric disorders. All subjects included in the current study are self-reported AA or EA. Subjects were re-classified as AA or EA on the basis of 41 ancestry informative genetic markers (AIMs) using STRUCTURE, as described previously (20, 37). Among the subjects included in current study, 3% of the subjects reporting to be of AA descent clustered in the EA group, and 2% of subjects reporting to be EA clustered in the AA group.