The 3-D brain connectivity map of significant DMN connections, which contributed to group classification, is shown in Figure 5. Compared to the CTL group, AUD individuals showed hyperconnectivity in five of the significant DMN connections (orange lines), while showing hypoconnectivity in the remaining nine connections (cyan lines). Specifically, the AUD group showed hyperconnectivity across bilateral ACC and PFC as well as between bilateral PCC and left IPL, while showing hypoconnectivity across other regions primarily involving anterior–posterior and interhemispheric long-range connections.
