function in reward circuitry during adolescent development [34], [58], [59], studies must also account for developmental processes as well as alcohol exposure and addiction as longitudinal influences on reward circuitry. More specifically, prospective studies should examine changes in VS response (i.e., possible decreases in sensitivity to non-drug reward stimuli over time), PFC response (i.e., stably low or decreasing level of response to reward), and frontostriatal connectivity (i.e., negative correlation between VS response and PFC response during reward processing).
